Category: Press Release

Ossium Health to Present New Clinical Data on Its Organ Donor Bone Marrow at ASH 2025

SAN FRANCISCO–(BUSINESS WIRE)–Ossium Health, a bioengineering company that developed a first-of-its-kind bank of bone marrow available on-demand, will present new clinical data at the at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition held December 6-9, 2025 in Orlando, Florida.

Ossium’s key abstract includes clinical data from four patients with hematologic malignancies that were treated with hematopoietic stem cells derived from the vertebral bodies of deceased organ donors. All four patients achieved rapid neutrophil engraftment, platelet recovery, and full donor chimerism. All cases of acute GVHD were successfully managed with steroids and no chronic GVHD was reported. By Day 180, all evaluatable patients were alive and relapse-free. These early results indicate that Ossium’s deceased-donor-derived bone marrow is a promising new graft source that supports robust engraftment while addressing both relapse and GVHD prevention.

The abstract is now available online:

High-dose cryopreserved bone marrow from deceased donors may reduce relapse in HLA-mismatched allogeneic transplantation: Day 180 post-transplant HOPE update
Abstract Number: 5976
Presenter: Sagar Munjal, MD, MS (Chief Medical Officer, Ossium Health)
Date/Time: Monday, December 8, 06:00 PM – 08:00 PM EST
Poster Session: 721. Allogeneic Transplantation: Conditioning Regimens, Engraftment, and Acute Toxicities: Poster III

Ossium’s presence at ASH 2025 underscores the company’s commitment to improving access, speed, and quality in hematopoietic cell transplantation. By presenting new clinical and scientific data and engaging directly with leaders in the hematology community, the company aims to raise awareness to how organ donor bone marrow is driving meaningful therapeutic advantages and overcoming longstanding donor availability limitations.

“We’re excited to share our latest clinical insights with the hematology community at ASH,” said Kevin Caldwell, Ossium’s CEO, Co-Founder & President. “Our findings demonstrate the potential of organ donor bone marrow to transform patient outcomes, and we look forward to engaging with clinicians and researchers at our booth.”

In addition to its presentation, Ossium Health will host an exhibit at Booth 112, where attendees can learn more about the company’s organ donor-derived bone marrow and its clinical programs.

About Ossium Health

Ossium Health is a bioengineering company that leverages its proprietary organ donor bone marrow banking platform to develop stem cell therapies for patients with life-threatening hematologic conditions, organ transplant rejection, and musculoskeletal defects. Founded in 2016, the company is led by Kevin Caldwell, Chief Executive Officer, President and Co-Founder, and Erik Woods, Chief Science Officer, Executive Vice President and Co-Founder. Ossium Health’s manufacturing facility is registered with the FDA and its laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA). For more information, please visit https://ossiumhealth.com.

Follow the company on LinkedIn at https://www.linkedin.com/company/ossiumhealth/ and X at https://x.com/ossiumhealth.

Contacts

Jane Griffin
Ossium Health, Inc.
415-513-5535
[email protected]

Susannah Cantrell Joins Ossium Health as Chief Commercial Officer

SAN FRANCISCO–(BUSINESS WIRE)–Ossium Health, a bioengineering company dedicated to improving human health through its organ donor bone marrow banking platform, announced today that Dr. Susannah Cantrell, PhD, has joined its leadership team as Chief Commercial Officer (CCO).

In her new role, Dr. Cantrell will be responsible for leading Ossium’s commercial strategy, go-to-market planning, and partnerships as the company scales its unique platform to meet the needs of the bone marrow transplant field. She will play a critical role in driving the company’s platform from development into full-scale commercial availability.

“Susannah brings a rare combination of commercial leadership, scientific rigor, and operational excellence — exactly what Ossium needs as we advance our platform,” said Kevin Caldwell, Co-Founder & CEO of Ossium Health. “Her track record of building high-performing commercial teams, especially in complex, regulated environments, will be invaluable as we expand adoption of our organ donor bone marrow.”

Dr. Cantrell brings more than two decades of experience in biotechnology and pharmaceuticals. Most recently, she served as Chief Business Officer at Brii Biosciences where she oversaw business development, alliance management, and commercial activities.

Prior to Brii Biosciences, Dr. Cantrell served as Chief Business Officer and Chief Operating Officer at Second Genome, where she oversaw the company’s operations, business development, finance, and facilities. Dr. Cantrell also served as Executive Vice President & Chief Commercial Officer at Tricida, where she built a U.S.-focused commercial organization from the ground up. She held senior leadership roles at Gilead Sciences, including Vice President, Global Commercial Strategy & Marketing – Oncology, where she played a key part in growing Gilead’s oncology and inflammation business lines. Earlier in her career, Dr. Cantrell held various global sales and marketing roles at Genentech/Roche and GlaxoSmithKline.

Dr. Cantrell holds a B.A. in Biology from Westminster College and a Ph.D. in Biochemistry from the University of Missouri-Columbia.

“I am thrilled to join Ossium Health at such an exciting time in its journey,” said Dr. Cantrell. “Their platform has the potential to fundamentally change how we think about cell therapy, and I look forward to working with the team to bring those innovations to patients.”

Her appointment marks a significant step in strengthening Ossium’s leadership as the company prepares for its next phase of growth, advancing commercial readiness and supporting the upcoming launch of its bone marrow at transplant centers nationwide.

About Ossium Health

Ossium Health is a bioengineering company that leverages its proprietary organ donor bone marrow banking platform to develop stem cell therapies for patients with life-threatening hematologic conditions, organ transplant rejection, and musculoskeletal defects. Founded in 2016, the company is led by Kevin Caldwell, Chief Executive Officer, President and Co-Founder, and Erik Woods, Chief Science Officer, Executive Vice President and Co-Founder. Ossium Health’s manufacturing facility is registered with the FDA and its laboratory is certified under the Clinical Laboratory Improvement Amendments (CLIA). For more information, please visit https://ossiumhealth.com.

Follow the company on LinkedIn at https://www.linkedin.com/company/ossiumhealth/ and X at https://x.com/ossiumhealth.

Contacts

Jane Griffin
Ossium Health, Inc.
415-513-5535
[email protected]

Ossium to Exhibit at Tandem in Honolulu

We’re excited to announce that Ossium will be exhibiting at the 2025 Transplantation & Cellular Therapy (Tandem) Meetings of ASTCT and CIBMTR, taking place from February 12-15 in Honolulu, Hawaii. This premier event brings together experts and professionals in the field of transplantation and cellular therapy to discuss the latest advancements, research, and innovations shaping the future of patient care.

Ossium is dedicated to revolutionizing the field of cell therapy and transplantation with our proprietary bone marrow banking platform. We are thrilled to engage with the global transplant community at Tandem 2025 and share how our innovative graft source is improving the access, speed, and quality of transplants for patients.

Visit us at Booth 629 to connect with our team and learn more about the company’s latest developments, including:

  • PRESERVE I Clinical Trial: This ongoing trial is actively recruiting patients and aims to evaluate allogeneic HCT with Ossium’s organ donor bone marrow for patients with hematologic malignancies.
  • HOPE Program: Ossium’s expanded access program is available for patients in need of an allogeneic HCT that are unable to enroll in PRESERVE I.

For more details, read our full press release here.

We look forward to seeing you in Honolulu!

Ossium Health Secures BARDA Contract to Advance Bone Marrow Bank for Radiological and Nuclear Emergencies

Ossium Health, a commercial-stage bioengineering company with the first-of-its-kind bone marrow bank for processing and deploying stem cell-based therapies, today announced the signing of a contract with the Biomedical Advanced Research and Development Authority (BARDA), part of the Administration for Strategic Preparedness and Response within the U.S. Department of Health and Human Services, to advance the company’s ready-to-use bone marrow for national emergency preparedness. The contract, initially funded at $21 million for its base period, has the potential to reach a total value of $125 million with additional options spanning five years.

Read the full press release here.

Ossium Health Reports Positive Initial Outcomes for First Ever Leukemia Patient Treated with Organ Donor Derived Bone Marrow

Ossium Health, a clinical-stage bioengineering company that built a first-of-its-kind organ donor-derived bone marrow bank to deploy hematopoietic stem cells for blood cancer treatment, announced positive preliminary outcomes for its first leukemia patient.

In Detroit, a 68-year-old female diagnosed with acute myeloid leukemia required an urgent bone marrow transplant following an unsuccessful four-month search for a matching donor. Doctors at Henry Ford Health collaborated with Ossium in June to obtain and use Ossium’s stem cell product to treat the patient. Specifically, the patient received an infusion of 5.27 million CD34+ cells per kilogram of body weight from a donor that was a 4/8 HLA match to the patient. The doctors reported neutrophil engraftment by day 16 post-transplant and platelet engraftment by day 21. There have been no reported product-related adverse events to date.

Read the full press release here.

First Surgery with OssiGraft Prime Highlights its Exceptional Utility

Our next-generation viable bone matrix, OssiGraft Prime™, has been released and used in surgery for the first time.

OssiGraft Prime builds upon the success of Ossium’s established OssiGraft™ and incorporates innovative processing advancements. The result is a more cohesive product with a gum-like consistency precisely engineered to meet the demands of orthopedic and spine surgeons. The product’s optimized handling properties enable surgeons to precisely sculpt and apply the graft in the intended location with unprecedented precision and efficiency.

“OssiGraft Prime is by far the best product on the market. I actually said ‘wow!’ out loud in the OR when I handled it in surgery for the first time,” said Dr. Jason Piraino, a leader and educator in foot & ankle surgery. “This product exceeded my expectations. It’s moldable and stays exactly where you want it, which makes it ideal for minimally invasive surgery.”

The first surgery with OssiGraft Prime, an arthroscopic ankle fusion, required the graft to be precisely shaped and placed through a narrow incision, demonstrating the product’s unique value. Surgeons working with OssiGraft Prime benefit from its ability to consistently fill odd-shaped gaps and tight spaces, allowing them to push the boundaries of possibility in orthopedic procedures.

Read the full press release here.

Ossium Launches HOPE Program

Ossium recently introduced a new program that further expands access to Ossium’s bone marrow to patients around the globe. Through the HOPE (HPC Offered for PRESERVE Expansion) Program, patients that need an allogeneic bone marrow transplant but cannot participate in Ossium’s active clinical study (PRESERVE I) have a new opportunity to receive bone marrow from Ossium’s bank.

The goal of Ossium’s PRESERVE trials is to establish organ donor bone marrow as a new source of stem cells for hematologic reconstitution and unlock access to stem cell transplants for the thousands of patients who search unsuccessfully for a donor each year. Ossium launched the HOPE Program after recognizing the sheer volume of patients that need a bone marrow transplant but are unable to participate in the PRESERVE I study due to its eligibility criteria or the patient’s geography.

“Thousands of patients in the US and tens of thousands abroad desperately need a bone marrow transplant but can’t find a donor,” said Kevin Caldwell, Ossium’s CEO, Co-Founder & President. “The HOPE Program is intended to fill that gap.”

For more details, read the press release.

Lauren Barnes Joins Ossium Health’s Board of Directors

We’re thrilled to announce that we’ve elected Lauren Barnes to our Board of Directors. Barnes is a leading expert in healthcare product commercialization, pricing, reimbursement, market access, and managed markets for products spanning various market segments. This addition significantly bolsters our capacity to drive growth and deliver life-changing solutions for patients suffering from hematologic diseases, organ transplant rejection, and musculoskeletal defects.

“We’re delighted to welcome Lauren as the newest addition to the Ossium Board,” said Kevin Caldwell, Ossium’s CEO, Co-Founder & President. “Lauren brings a fresh perspective to our shared passion for advancing the health, vitality, and longevity of human beings. I’m confident that her valuable insights and expertise will meaningfully help Ossium as the company continues to grow and positively impact more patients.”

Barnes’ appointment underscores our dedication to assembling a world-class Board of Directors equipped with diverse perspectives and proven expertise. Her expertise in commercialization and market access strategy at biopharmaceutical companies in various stages of development complements the expertise of the incumbent board members and will further propel us toward our goals.

Read the press release here.

Lauren Barnes is Ossium’s newest board member