Hematologic Diseases
Expanding access to hematopoietic stem cell transplants for patients in need
Program
Phase 1
Phase 2
Phase 3
Commercial
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BMT Comparative Study
Phase 3
A multi-phase, multi-center clinical trial of partially HLA-mismatched (≥4/8), unrelated bone marrow for transplantation to treat hematologic malignancies (MDS, AML, CLL, ALL, etc.). The study will compare the effectiveness of mismatched Ossium HPC, Marrow to live donor haploidentical transplants.
Related Products
HPC, Marrow
Partners
NMDP / Be the Match / CIBMTR
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Micro Bone Marrow Transplants
Pre-Clinical
We are developing a safety and feasibility clinical trial for blood cancers where patients will receive a reduced (‘micro’) conditioning regimen and a mismatched bone marrow transplant using Ossium HPC, Marrow.
Related Products
HPC, Marrow
Partners
Columbia University
Organ Transplant Rejection
Allowing organ transplant recipients to lead healthy lives without immunosuppression
Program
Pre-Clinical
Phase 1
Phase 2
Phase 3
Commercial
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Multivisceral Transplantation
Phase 1
Phase 1 safety and feasibility clinical trial with the objective of inducing tolerance in intestinal transplant patients by establishing mixed Chimerism via infusion of Ossium’s selected CD34+ cells processed from the organ donor's bone marrow.
Related Products
Selected CD34+ Cells
Partners
Columbia University
Diseases of Inflammation
Modulating immune function and inflammation to treat diseases characterized by the presence of an inflammatory component
Program
Pre-Clinical
Phase 1
Phase 2
Phase 3
Commercial
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Crohn's Disease, Perianal Fistula
Phase 1
A Phase 1 study of culture-expanded adult allogeneic bone marrow derived mesenchymal stem cells (MSCs) for the treatment of refractory perianal fistulizing Crohn’s disease.
Related Products
MSCs
Partners
Cleveland Clinic
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Crohn's Disease, Pouch Fistula
Phase 1
Phase 1b/2a clinical trial determining the safety and effectiveness of a perilesional injection of BM-MSCs for the treatment of refractory pouch fistula Crohn’s disease (PFCD)
Related Products
MSCs
Partners
Cleveland Clinic
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Graft-versus-Host Disease (GVHD)
Phase 1
Open-label, non-randomized Phase 1b clinical trial evaluating the use of interferon gamma-primed MSCs to prevent graft-versus-host disease in adult and pediatric patients undergoing hematopoietic cell transplantation (HCT) for acute leukemia and myelodysplastic syndromes
Related Products
MSCs
Partners
Emory University
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Asthma
Phase 1
Phase 1 safety and efficacy clinical trial evaluating the use of interferon gamma-primed MSCs in children with moderate-to-severe persistent asthma.
Related Products
MSCs
Partners
Children's Healthcare of Atlanta